Parkinson's disease, DBS and suicide: a role for serotonin?
نویسندگان
چکیده
1 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA 2 Division of Neurology, Department of Medicine, University of Toronto, UHN, Toronto, Canada 3 Department of Neurology, University Joseph Fourier, Grenoble, France 4 Clinique Neurologique, Lille University Hospital, Lille, France 5 National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, France 6 Department of Neurology, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France 7 Department of Neurology, University of Milan, Italy 8 Department of Neurology, Christian-Albrechts-Universität Kiel, Kiel, Germany 9 Academic Medical Center of Amsterdam, Amsterdam, The Netherlands 10 Department of Psychiatry and Psychology, University of Arizona, Phoenix, AZ, USA 11 The Cleveland Clinic Foundation, OH, USA
منابع مشابه
Closed- and Open-loop Deep Brain Stimulation: Methods, Challenges, Current and Future Aspects
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...
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Abstract Introduction: It is demonstrated that the degree of clinical improvement in Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent on the accuracy of lead placement. In addition, individual variability in the situation of subthalamic nucleus (STN) is responsible for spatial inter-individual fluctuations of the real patient's target. Objecti...
متن کاملAttempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease.
A higher than expected frequency of suicide has been reported among patients undergoing subthalamic nucleus deep brain stimulation (STN DBS) for advanced Parkinson's disease (PD). We conducted a retrospective survey of 200 patients with PD who underwent STN DBS. Two patients (1%) committed suicide and four (2%) attempted suicide, despite clear motor improvements. Suicidal patients did not diffe...
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After Alzheimer's disease, Parkinson's disease is the most common nerve-damaging disease. Parkinson's is a progressive and chronic disease where cells secrete dopamine-cut black flesh and in the absence of dopamine in the brain destroyed the irregular body movements. Man eats the food that causes the formation of the neurotransmitters. Tthree neurotransmitters: dopamine, serotonin, norepinephri...
متن کاملLong-Term Mortality Analysis in Parkinson's Disease Treated with Deep Brain Stimulation
Background. Few data have been published regarding long-term mortality in patients with Parkinson's disease treated with DBS. Methods. This study analyzed long-term mortality rates, causes, and correlates in PD patients treated with DBS. Results. 184 consecutive patients were included; mean follow-up was 50 months. Fifteen deaths occurred (total 8.15%, annual mortality rate 1.94%). Mean age at ...
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ورودعنوان ژورنال:
- Brain : a journal of neurology
دوره 132 Pt 10 شماره
صفحات -
تاریخ انتشار 2009